Journal article
Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry: A High-Throughput Platform for Metabolomics with High Data Fidelity
Abstract
A major constraint in large-scale mass spectrometry (MS)-based metabolomic initiatives is the low sample throughput associated with chromatographic or electrophoretic separations. Herein, we introduce multisegment injection-capillary electrophoresis-mass spectrometry (MSI-CE-MS) as a multiplexed separation platform for metabolomics that increases sample throughput up to one order of magnitude while improving overall data fidelity. We …
Authors
Kuehnbaum NL; Kormendi A; Britz-McKibbin P
Journal
Analytical Chemistry, Vol. 85, No. 22, pp. 10664–10669
Publisher
American Chemical Society (ACS)
Publication Date
November 19, 2013
DOI
10.1021/ac403171u
ISSN
0003-2700