Journal article
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore
Abstract
Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.
Authors
McNulty J; Mao J; Gibe R; Mo R; Wolf S; Pettit GR; Herald DL; Boyd MR
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 11, No. 2, pp. 169–172
Publisher
Elsevier
Publication Date
January 2001
DOI
10.1016/s0960-894x(00)00614-4
ISSN
0960-894X