Journal article
Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells.
Abstract
The Amaryllidaceae alkaloid pancratistatin has been proven to selectively induce apoptotic cell death in a variety of human cancer cells with an insignificant effect on non-cancerous cells. In this study we report, for the first time, the effects of pancratistatin (PST) on models of metastatic prostate cancer. The effects of pancratistatin on prostate cancer DU145 and LNCaP cell lines was assessed by microscopy, enzymatic activity assays and …
Authors
Griffin C; McNulty J; Pandey S
Journal
International Journal of Oncology, Vol. 38, No. 6, pp. 1549–1556
Publisher
Spandidos Publications
Publication Date
6 2011
DOI
10.3892/ijo.2011.977
ISSN
1019-6439