The First Well‐Defined Silver(I)‐Complex‐Catalyzed Cycloaddition of Azides onto Terminal Alkynes at Room Temperature

Silver(I)‐catalyzed click chemistry: Substituted 1,2,3‐triazoles are versatile intermediates with an expanding array of applications. The discovery and application of a general AgI‐catalyzed azide–alkyne cycloaddition reaction (AAC) leading to 1,2,3‐triazoles is reported. The synthesis of a stable, well‐defined AgI complex of type [AgI(L2)(OAc)] is described, along with the unprecedented ability of this complex to promote the general Ag‐AAC at room temperature (see scheme).