Journal article
Carbon monoxide-releasing molecule CORM-3 suppresses vascular endothelial cell SOD-1/SOD-2 activity while up-regulating the cell surface levels of SOD-3 in a heparin-dependent manner
Abstract
The role of CO in the modulation of antioxidant enzyme function has not been investigated, yet. In this study we assessed the effects and potential mechanisms of the ruthenium-based water-soluble CO-releasing molecule CORM-3 in the modulation of superoxide dismutase (SOD) activity/binding in vascular endothelial cells (HUVECs). To this end, HUVECs were treated with CORM-3 (100 μM) and assessed for total SOD activity in cell lysates …
Authors
Mizuguchi S; Capretta A; Suehiro S; Nishiyama N; Luke P; Potter RF; Fraser DD; Cepinskas G
Journal
Free Radical Biology and Medicine, Vol. 49, No. 10, pp. 1534–1541
Publisher
Elsevier
Publication Date
November 2010
DOI
10.1016/j.freeradbiomed.2010.08.017
ISSN
0891-5849