Journal article
Carbon Monoxide–Releasing Molecule-401 Suppresses Polymorphonuclear Leukocyte Migratory Potential by Modulating F-Actin Dynamics
Abstract
Carbon monoxide-releasing molecules (CORMs) suppress inflammation by reducing polymorphonuclear leukocyte (PMN) recruitment to the affected organs. We investigated modulation of PMN-endothelial cell adhesive interactions by water-soluble CORM-401 using an experimental model of endotoxemia in vitro. Human umbilical vein endothelial cells (HUVEC) grown on laminar-flow perfusion channels were stimulated with 1 μg/mL lipopolysaccharide for 6 hours …
Authors
Inoue K; Patterson EK; Capretta A; Lawendy AR; Fraser DD; Cepinskas G
Journal
American Journal Of Pathology, Vol. 187, No. 5, pp. 1121–1133
Publisher
Elsevier
Publication Date
May 2017
DOI
10.1016/j.ajpath.2016.12.025
ISSN
0002-9440