Journal article
Teratogenic Effects of Mild Heat Stress during Mouse Embryogenesis: Effect of Trp53
Abstract
Hyperthermia can be teratogenic in fetal mice exposed during organogenesis, an effect considered to be due to heat-induced apoptosis of cells in the developing organs. We exposed pregnant mice carrying Trp53(+/+), Trp53(+/-) and Trp53(-/-) fetuses to mild whole-body hyperthermia that raised their core temperature to 40.5 degrees C for 60 min on either day 10 or 11 of gestation. On day 18 of gestation, the fetuses were removed from control and …
Authors
Boreham DR; Dolling J-A; Misonoh J; Mitchel REJ
Journal
Radiation Research, Vol. 158, No. 4, pp. 443–448
Publisher
Radiation Research Society
Publication Date
October 2002
DOI
10.1667/0033-7587(2002)158[0443:teomhs]2.0.co;2
ISSN
0033-7587