Fluorous Analogue of Chloramine-T: Preparation, X‑ray Structure Determination, and Use as an Oxidant for Radioiodination and s‑Tetrazine Synthesis

A fluorous oxidant that can be used to introduce radioiodine into small molecules and proteins and generate iodinated tetrazines for bioorthogonal chemistry has been developed. The oxidant was prepared in 87% overall yield by combining a fluorous amine with tosyl chloride, followed by chlorination using aqueous sodium hypochlorite. A crystal structure of the oxidant, which is a fluorous analogue of chloramine-T, was obtained. The compound was …