Experience-Dependent Changes in Excitatory and Inhibitory Receptor Subunit Expression in Visual Cortex

Experience-dependent development of visual cortex depends on the balance between excitatory and inhibitory activity. This activity is regulated by key excitatory (NMDA, AMPA) and inhibitory (GABA(A)) receptors. The composition of these receptors changes developmentally, affecting the excitatory-inhibitory (E/I) balance and synaptic plasticity. Until now, it has been unclear how abnormal visual experience affects this balance. To examine this …