Process‐aware data‐driven modelling and model predictive control of bioreactor for the production of monoclonal antibodies

Abstract This manuscript addresses the problem of controlling a bioreactor to maximize the production of a desired product while respecting the constraints imposed by the nature of the bio‐process. The approach is demonstrated by first building a data‐driven model and then formulating a model predictive controller (MPC) with the results illustrated by implementing a detailed monoclonal antibody production model (the test bed) created by …