Predicting the Volume Phase Transition Temperature of Multi-Responsive Poly(N‑isopropylacrylamide)-Based Microgels Using a Cluster-Based Partial Least Squares Modeling Approach

Despite the various potential applications of dual pH/temperature-responsive microgels, the multiple (and often interacting) physical and chemical factors that influence the volume phase transition temperature (VPTT) in such microgels make it challenging to directly design a microgel with a particular targeted swelling response. Herein, we address this challenge by designing and implementing a data-driven model that can predict a microgel …