Journal article
Experimental modification of PC12 neurite shape with the microtubule-depolymerizing drug Nocodazole: a serial electron microscopic study of neurite shape control.
Abstract
The microtubule-depolymerizing drug Nocodazole has been used to experimentally manipulate the form of PC12 neurites. Both time-lapse photography and serial electron microscopy demonstrate that microtubule depolymerization leads to varicosity formation due to a clustering of membranous organelles in young neurites (nerve growth factor activated within 7 d). Neurites that have been nerve growth factor activated 7 or more d before Nocodazole …
Authors
Jacobs JR; Stevens JK
Journal
Journal of Cell Biology, Vol. 103, No. 3, pp. 907–915
Publisher
Rockefeller University Press
Publication Date
September 1, 1986
DOI
10.1083/jcb.103.3.907
ISSN
0021-9525