Synthesis of an optically transparent poly(N-isopropylacrylamide)-based thermally gelling material

Restrictive barriers and efficient clearance mechanisms make delivery of therapeutics to the back of the eye particularly challenging. An optically transparent, thermally gelling copolymer scaffold that can simply be mixed with an active pharmaceutical ingredient of choice and injected directly into the vitreous chamber has been designed. The poly( N-isopropylacrylamide) (PNIPAAm)-based copolymer possesses a lower critical solution temperature …