Screening amino acid additives as aerosolization modifiers for spray dried inhalable viral-vectored vaccines

Adenoviral vectored vaccines are a promising platform for immunization against respiratory diseases. Despite the advantages offered by dry powder over parenteral administration, like thermal stability and possible immunization at the site of infection, aerosolization of such dry powders is challenging. In this study, eight amino acids were investigated to improve the aerosolization of spray-dried human adenovirus type 5 (AdHu5) in a …