Conference
Thermo-responsive and mucoadhesive gels for the treatment of cystinosis
Abstract
Mucoadhesive thermogels were developed by crosslinking poly(n-isopropylacrylamide) based polymers with chitosan and incorporating disulfide bridges, capable of releasing cysteamine upon interaction with mucin, for the treatment of cystinosis. Through crosslinking with chitosan and incorporating varying concentrations of the disulfide monomer into the polymer backbone, the extent of how mucoadhesive the developed thermogels were could be …
Authors
Ross M; Mofford J; Tian JJ; Muirhead B; Hicks EA; Sheardown L; Sheardown H
Volume
144
Publisher
Elsevier
Publication Date
1 2023
DOI
10.1016/j.bioadv.2022.213235
Conference proceedings
Biomaterials Advances
ISSN
2772-9516