Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons

Recombinant adenovirus vectors have provided a major advance in gene delivery systems for post-mitotic neurons. however, the use of these first generation vectors has been limited due to the onset of virally mediated effects on cellular function and viability. in the present study we have used primary cultures of cerebellar granule neurons to examine the efficacy and cytotoxic effects of a helper-dependent adenovirus vector (hdad) in comparison …