Sex-specific effects of chronic hypoxia on routine cardiovascular function and metabolism in CD-1 mice

Hypoxia can have significant impacts on cardiovascular physiology, but the effects of chronic exposure to moderate hypoxia and how they differ between sexes remain poorly understood. We used physiological telemetry to examine this issue in CD-1 mice. Adult mice were chronically exposed to normoxia or hypobaric hypoxia (12 kPa O₂) for 6 wk and then subjected to telemetry measurements of routine physiology across the diel cycle. Heart rate (f_H), …