Journal article
Consecutive Inhibition of Telomerase and Alternative Lengthening Pathway Promotes Hodgkin’s Lymphoma Cell Death
Abstract
Telomere maintenance is key during cancer development. Malignant cells can either use telomerase or an alternative lengthening of telomere (ALT) pathway to maintain their telomere length. In Hodgkin's Lymphoma (HL), the presence of telomerase activation is established. The activation of ALT has been reported recently. Our data confirm this notion describing co-localization of the phosphorylated form of telomeric repeat-binding factor 1 …
Authors
Lima MFD; Freitas MO; Hamedani MK; Rangel-Pozzo A; Zhu X-D; Mai S
Journal
Biomedicines, Vol. 10, No. 9,
Publisher
MDPI
DOI
10.3390/biomedicines10092299
ISSN
2227-9059