Journal article
A pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solutions in open fractures (Aqueous-PREP): statistical analysis plan
Abstract
BackgroundApproximately 1 in 10 patients with a surgically treated open fracture will develop a surgical site infection. The Aqueous-PREP trial will investigate the effect of 10% povidone-iodine versus 4% chlorhexidine in aqueous antiseptic solutions in reducing infections after open fracture surgery. The study protocol was published in April 2020.Methods and designThe Aqueous-PREP trial is a pragmatic, multicenter, open-label, randomized …
Authors
O’Hara NN; Heels-Ansdell D; Bzovsky S; Dodds S; Thabane L; Bhandari M; Guyatt G; Devereaux PJ; Slobogean GP; Sprague S
Journal
Trials, Vol. 23, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13063-022-06541-0
ISSN
1468-6708