Antithrombin-III-Stockholm: A Codon 392 (Gly → Asp) Mutation With Normal Heparin Binding and Impaired Serine Protease Reactivity

Abstract Antithrombin-III-Stockholm is a new structural variant of antithrombin- III (AT-III) with normal heparin affinity but defective serine protease inhibitory activity. The proposita, a white female born in 1966, was diagnosed to have developed a pulmonary embolus while on oral contraceptives at age 19. The proposita, as well as her father, were diagnosed to have a type 2 AT-III deficiency as they had normal levels of …