Journal article
Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis
Abstract
Sex differences in the prevalence and development of diabetes and associated cardiometabolic complications are well established. The objective of this study was to analyze the effects of estrogen on the maintenance of β-cell health/function and atherosclerosis progression, using a mouse model of hyperglycemia-induced atherosclerosis, the ApoE-/-:Ins2+/Akita mouse. ApoE-/-:Ins2+/Akita mice exhibit sexual dimorphism in the control of blood …
Authors
De Paoli M; Wood DW; Bohn MK; Pandey AK; Borowitz DK; Fang S; Patel Z; Venegas-Pino DE; Shi Y; Werstuck GH
Journal
AJP Endocrinology and Metabolism, Vol. 323, No. 3, pp. e254–e266
Publisher
American Physiological Society
Publication Date
September 1, 2022
DOI
10.1152/ajpendo.00353.2021
ISSN
0193-1849