Journal article
Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status
Abstract
Metastatic prostate cancer is a lethal disease in patients incapable of responding to therapeutic interventions. Invasive prostate cancer spread is caused by failure of the normal anti-cancer defense systems that are controlled by the tumour suppressor protein, p53. Upon mutation, p53 malfunctions. Therapeutic strategies to directly re-empower the growth-restrictive capacities of p53 in cancers have largely been unsuccessful, frequently because …
Authors
Mejía-Hernández JO; Raghu D; Caramia F; Clemons N; Fujihara K; Riseborough T; Teunisse A; Jochemsen AG; Abrahmsén L; Blandino G
Journal
Cancers, Vol. 14, No. 16,
Publisher
MDPI
DOI
10.3390/cancers14163947
ISSN
2072-6694