Journal article
Human coronaviruses disassemble processing bodies
Abstract
A dysregulated proinflammatory cytokine response is characteristic of severe coronavirus infections caused by SARS-CoV-2, yet our understanding of the underlying mechanism responsible for this imbalanced immune response remains incomplete. Processing bodies (PBs) are cytoplasmic membraneless ribonucleoprotein granules that control innate immune responses by mediating the constitutive decay or suppression of mRNA transcripts, including many that …
Authors
Kleer M; Mulloy RP; Robinson C-A; Evseev D; Bui-Marinos MP; Castle EL; Banerjee A; Mubareka S; Mossman K; Corcoran JA
Journal
PLOS Pathogens, Vol. 18, No. 8,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.ppat.1010724
ISSN
1553-7366