Journal article
Reduced Metabotropic Glutamate Receptor Type 5 Availability in the Epileptogenic Hippocampus: An in vitro Study
Abstract
Abnormalities in the expression of metabotropic glutamate receptor type 5 (mGluR5) have been observed in the hippocampus of patients with drug-resistant mesial Temporal Lobe Epilepsy (mTLE). Ex-vivo studies in mTLE hippocampal surgical specimens have shown increased mGluR5 immunoreactivity, while in vivo whole brain imaging using positron emission tomography (PET) demonstrated reduced hippocampal mGluR5 availability. To further understand …
Authors
Zimmermann M; Minuzzi L; Aliaga AA; Guiot M-C; Hall JA; Soucy J-P; Massarweh G; Mestikawy SE; Rosa-Neto P; Kobayashi E
Journal
Frontiers in Neurology, Vol. 13, ,
Publisher
Frontiers
DOI
10.3389/fneur.2022.888479
ISSN
1664-2295