Journal article
Quantitative analysis of regions of adenovirus E1A products involved in interactions with cellular proteins
Abstract
Human adenovirus E1A proteins and oncogene products of several other DNA tumour viruses derive much of their oncogenic potential from interactions with cellular polypeptides. E1A proteins form complexes with p105Rb and a related p107 polypeptide, and with at least three other proteins (p60cycA, p130, and p300); all may be required for cell transformation. Using a series of E1A deletion mutants, we have carried out a quantitative analysis of the …
Authors
Barbeau D; Marcellus RC; Bacchetti S; Bayley ST; Branton PE
Journal
Biochemistry and Cell Biology, Vol. 70, No. 10-11, pp. 1123–1134
Publisher
Canadian Science Publishing
Publication Date
October 1, 1992
DOI
10.1139/o92-158
ISSN
0829-8211