Journal article
TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer
Abstract
The Telomeric Repeat binding Factor 2 (TRF2), a key protein involved in telomere integrity, is over-expressed in several human cancers and promotes tumor formation and progression. Recently, TRF2 has been also found outside telomeres where it can affect gene expression. Here we provide evidence that TRF2 is able to modulate the expression of microRNAs (miRNAs), small non-coding RNAs altered in human tumors. Among the miRNAs regulated by TRF2, …
Authors
Dinami R; Petti E; Porru M; Rizzo A; Ganci F; Sacconi A; Ostano P; Chiorino G; Trusolino L; Blandino G
Journal
Cancer Letters, Vol. 533, ,
Publisher
Elsevier
Publication Date
5 2022
DOI
10.1016/j.canlet.2022.215607
ISSN
0304-3835