Journal article
Role of matrix metalloprotease-2 and MMP-9 in experimental lung fibrosis in mice
Abstract
BackgroundIdiopathic pulmonary fibrosis (IPF) is a diffuse parenchymal lung disease characterized by exuberant deposition of extracellular matrix (ECM) proteins in the lung interstitium, which contributes to substantial morbidity and mortality in IPF patients. Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endopeptidases, many of which have been implicated in the regulation of ECM degradation in lung fibrosis. However, …
Authors
Bormann T; Maus R; Stolper J; Tort Tarrés M; Brandenberger C; Wedekind D; Jonigk D; Welte T; Gauldie J; Kolb M
Journal
Respiratory Research, Vol. 23, No. 1,
Publisher
Springer Nature
Publication Date
December 2022
DOI
10.1186/s12931-022-02105-7
ISSN
1465-9921