Journal article
Use of Vinyl Sulfides in Fischer Indole Reactions
Abstract
Abstract
Vinyl sulfides accessed via Wittig olefination with thioalkylphosphonium salts are used as aldehyde- or ketone surrogates in Fischer indole reactions. These vinyl sulfides react with arylhydrazines in the presence of TsOH·H2O in refluxing ethanol or dichloroethane to yield diverse 3-substituted and 2,3-disubstituted indoles or azaindoles. The utility of this chemistry is highlighted with the efficient preparation of …
Authors
Pal P; Fragis M; Magolan J; Dharavath S; Johnson JW
Journal
Synthesis, Vol. 54, No. 22, pp. 4917–4931
Publisher
Thieme
Publication Date
11 2022
DOI
10.1055/a-1868-4148
ISSN
0039-7881