Noradrenergic signal transfer as a target of antidepressant therapy

Neurohormones such as norepinephrine (NE), serotonin (5-HT) and dopamine (DA) are, like hormones, informational molecules that transmit specific sets of instructions through specific membrane receptors from the outside to the inside of the cell. While research on the mode of action of antidepressant drugs has centered in the past on their effects on synthesis, release, metabolism, reuptake and hence the availability of neurohormones such as NE …