Cigarette Smoke Condensate Inhibits Follicular Development, Oocyte Maturation, and Dysregulates Steroids Synthesis In Vitro: Implications for Human Fecundity.

Decreased fertility and poorer response to ovulation induction have been reported in women who smoke compared to non-smokers. The cytotoxic effects and underlying mechanisms of action of cigarette smoke on ovarian function are poorly defined. We therefore hypothesize that cigarette smoke condensate (CSC) will affect follicular development, steroidogenesis, cumulus cell differentiation and oocyte maturity. Isolated mouse follicles (100-130 µm) …