Journal article
Abstract 564: Targeting axonal guidance with anti-ROBO1 CAR T cells: A new therapeutic strategy for malignant brain cancer
Abstract
Abstract
No standardized treatment exists for patients with recurrent glioblastoma (GBM). Given the aggressive nature of the disease and difficulty in modeling tumor recurrence, minimal efforts have been made to design rational therapies against it. The roundabout guidance receptor 1 (ROBO1) protein is involved in axonal guidance during neurodevelopment and is aberrantly upregulated in glioma where it mediates glioma cell …
Authors
Singh SK; Chokshi CR; Brakel B; Rossotti MA; Venugopal C; Salim S; Henry K
Journal
Cancer Research, Vol. 82, No. 12_Supplement, pp. 564–564
Publisher
American Association for Cancer Research (AACR)
Publication Date
June 15, 2022
DOI
10.1158/1538-7445.am2022-564
ISSN
0008-5472