The Role of Coactivator‐associated Arginine Methyltransferase 1 (CARM1) During Sarcopenia

CARM1 is emerging as an important regulator of skeletal muscle plasticity. We recently reported reduced muscle mass, along with aberrant autophagic and atrophic signaling in CARM1 skeletal muscle‐specific knockout (mKO) mice. Notably, CARM1 interacts with forkhead box O1 (FOXO1), a master transcriptional regulator of the atrophy program, and knockout of CARM1 in skeletal muscle results in elevated FOXO1 protein content. Although CARM1 appears …