Journal article
Aerobic exercise elicits clinical adaptations in myotonic dystrophy type 1 patients independent of pathophysiological changes
Abstract
BackgroundMyotonic dystrophy type 1 (DM1) is a complex life-limiting neuromuscular disorder characterized by severe skeletal muscle atrophy, weakness, and cardiorespiratory defects. Exercised DM1 mice exhibit numerous physiological benefits that are underpinned by reduced CUG foci and improved alternative splicing. However, the efficacy of physical activity in patients is unknown.MethodsEleven genetically diagnosed DM1 patients were recruited …
Authors
Mikhail AI; Nagy PL; Manta K; Rouse N; Manta A; Ng SY; Nagy MF; Smith P; Lu J-Q; Nederveen JP
Journal
Journal of Clinical Investigation, Vol. 132, No. 10,
Publisher
American Society for Clinical Investigation
Publication Date
May 16, 2022
DOI
10.1172/jci156125
ISSN
0021-9738