O2‐sensing in immortalized rat adrenomedullary chromaffin (MAH) cells: Role of mitochondria and ROS signaling

Hypoxia‐induced catecholamine (CA) release from neonatal adrenomedullary chromaffin cells (AMC) is critical during the adaptation of the newborn to extrauterine life and is facilitated by inhibition of O2−sensitive K+ channels. Using a surrogate model based on a v‐myc immortalized adrenal chromaffin cell line (i.e. MAH cells), which shares several O2 sensing properties with neonatal AMC, we tested the hypothesis that mitochondrial function and …