Deregulation of Control of Growth and Apoptosis Occurs with Age or Exposure to Certain Mutagens in Normal Human Cells; A Possible Predictive Test for Cancer Risk

The identification of sub populations at increased risk from carcinogenic agents in the workplace or environment is a major healthcare goal. General screening is costly and reduction of risk to negligible levels is impractical if not impossible. Attempts to categorise people on the basis of predisposition have only worked in a few cases where an inherited cancer syndrome exists. Recent advances in our understanding of initial events in cancer …