Journal article
TRTH-13. BMI1 IS A THERAPEUTIC TARGET IN RECURRENT MEDULLOBLASTOMA
Abstract
Abstract Bmi1 is a master regulatory stem cell self-renewal gene and epigenetic regulator that presents a downstream target of developmental pathways active during the genesis of the childhood brain tumor medulloblastoma (MB). Here, we describe Bmi1 as a novel therapeutic target for the treatment of recurrent human Group 3 MB, a tumor that often presents with metastasis for which there is virtually no treatment option as children are limited to …
Authors
Bakhshinyan D; Garg N; Manoranjan B; Venugopal C; Hallett R; Wang X; Kameda-smith M; Adile A; Ramaswamy V; Davis T
Journal
Neuro-oncology, Vol. 19, No. Suppl 4, pp. iv54–iv54
Publication Date
5 2017
ISSN
1522-8517