Journal article
Evolution of Proteasome Regulators in Eukaryotes
Abstract
All living organisms require protein degradation to terminate biological processes and remove damaged proteins. One such machine is the 20S proteasome, a specialized barrel-shaped and compartmentalized multicatalytic protease. The activity of the 20S proteasome generally requires the binding of regulators/proteasome activators (PAs), which control the entrance of substrates. These include the PA700 (19S complex), which assembles with the 20S …
Authors
Fort P; Kajava AV; Delsuc F; Coux O
Journal
Genome Biology and Evolution, Vol. 7, No. 5, pp. 1363–1379
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 2015
DOI
10.1093/gbe/evv068
ISSN
1759-6653