Journal article
The Role of Airway Epithelial Cell Alarmins in Asthma
Abstract
The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly. Activation of pattern recognition receptors triggers the release of alarmin cytokines IL-25, IL-33, and TSLP. These alarmins are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune …
Authors
Whetstone CE; Ranjbar M; Omer H; Cusack RP; Gauvreau GM
Journal
Cells, Vol. 11, No. 7,
Publisher
MDPI
DOI
10.3390/cells11071105
ISSN
2073-4409