Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders

T cells are the current choice for many cell therapy applications. They are relatively easy to access, expand in culture, and genetically modify. Rapamycin‐conditioning ex vivo reprograms T cells, increasing their memory properties and capacity for survival, while reducing inflammatory potential and the amount of preparative conditioning required for engraftment. Rapamycin‐conditioned T cells have been tested in patients and deemed to be safe …