Early neonatal heart rate variability patterns in different subtypes of perinatal hypoxic-ischemic brain injury

BackgroundThis study aims to compare the longitudinal changes in heart rate variability (HRV) during therapeutic hypothermia in neonates with different subtypes of hypoxic-ischemic brain injury.MethodsHRV was computed from 1 hour time-epochs q6 hours for the first 48 hours. Primary outcome was brain-injury pattern on MRI at 4(3–5) days. We fitted linear mixed-effect regression models with HRV metric, brain injury subtype and postnatal …