Conference
Abstract PR009: The functional genomic landscape of recurrent glioblastoma
Abstract
Abstract
Glioblastoma (GBM) is a highly fatal brain cancer where mortality is predominantly caused by disease recurrence and lack of second-line therapies. Here, utilizing genome-wide CRISPR-Cas9 screening, we uncover treatment-based conditional genetic interactions modulating sensitivity to combined radiation therapy (RT) and temozolomide (TMZ), the standard of care treatment administered to over 70% of glioblastoma patients. …
Authors
Chokshi C; Tieu D; Brown K; Venugopal C; Liu L; Kuhlman L; Chan K; Tong A; Savage N; McKenna D
Volume
9
Pagination
pp. pr009-pr009
Publisher
American Association for Cancer Research (AACR)
Publication Date
February 1, 2021
DOI
10.1158/2326-6074.tumimm20-pr009
Conference proceedings
Cancer Immunology Research
Issue
2_Supplement
ISSN
2326-6066