BSCI-19. Therapeutic intervention of lung-, breast-, and melanoma-brain metastasis

The incidence of brain metastases (BM) is tenfold higher than that of primary brain tumours. BM predominantly originate from primary lung, breast, and melanoma tumours with a 90% mortality rate within one year of diagnosis, posing a large unmet clinical need to identify novel therapies against BM.

Using a large in-house biobank of patient-derived BM cell lines, the Singh Lab has generated murine orthotopic …