Journal article
A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion
Abstract
Insulin resistance and β-cell dysfunction are two main molecular bases yet to be further elucidated for type 2 diabetes (T2D). Accumulating evidence indicates that stimulator of interferon genes (STING) plays an important role in regulating insulin sensitivity. However, its function in β-cells remains unknown. Herein, using global STING knockout (STING-/-) and β-cell-specific STING knockout (STING-βKO) mouse models, we revealed a distinct role …
Authors
Qiao J; Zhang Z; Ji S; Liu T; Zhang X; Huang Y; Feng W; Wang K; Wang J; Wang S
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 7,
Publisher
Proceedings of the National Academy of Sciences
Publication Date
February 15, 2022
DOI
10.1073/pnas.2101848119
ISSN
0027-8424