Journal article
AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma
Abstract
Epithelial ovarian cancer is the deadliest gynecological malignancy. The lack of effective treatments highlights the need for novel therapeutic interventions. The aim of this study was to investigate whether sustained adeno-associated virus (AAV) vector-mediated expression of vascular normalizing agents 3TSR and Fc3TSR and the antiangiogenic monoclonal antibody, Bevacizumab, with or without oncolytic virus treatment would improve survival in an …
Authors
Stegelmeier AA; Santry LA; Guilleman MM; Matuszewska K; Minott JA; Yates JGE; Stevens BAY; Thomas SP; Vanderkamp S; Hanada K
Journal
Biomedicines, Vol. 10, No. 2,
Publisher
MDPI
DOI
10.3390/biomedicines10020362
ISSN
2227-9059