Journal article
A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern
Abstract
We report on a unique DNA aptamer, denoted MSA52, that displays universally high affinity for the spike proteins of wildtype SARS-CoV-2 as well as the Alpha, Beta, Gamma, Epsilon, Kappa, Delta and Omicron variants. Using an aptamer pool produced from round 13 of selection against the S1 domain of the wildtype spike protein, we carried out one-round SELEX experiments using five different trimeric spike proteins from variants, followed by …
Authors
Zhang Z; Li J; Gu J; Amini R; Stacey HD; Ang JC; White D; Filipe CDM; Mossman K; Miller MS
Journal
Chemistry - A European Journal, Vol. 28, No. 15,
Publisher
Wiley
Publication Date
March 10, 2022
DOI
10.1002/chem.202200078
ISSN
0947-6539