Journal article
Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance
Abstract
Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However, the mechanism by which this occurs has not yet been uncovered. Here, we investigated the effect of CF on the expression of two bona fide regulators of circulating low-density lipoprotein cholesterol (LDLc) levels; the proprotein convertase subtilisin/kexin type 9 (PCSK9) and the low-density lipoprotein receptor (LDLR). Following the observation that CF …
Authors
Lebeau PF; Byun JH; Platko K; Saliba P; Sguazzin M; MacDonald ME; Paré G; Steinberg GR; Janssen LJ; Igdoura SA
Journal
Nature Communications, Vol. 13, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-022-28240-9
ISSN
2041-1723