Journal article
Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates
Abstract
Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment1,2. However, this therapeutic strategy has not been systematically assessed in large animal models physiologically similar to humans, such as non-human primates3. In this study, we generated islets from human chemically induced pluripotent stem cells (hCiPSC-islets) and show that a one-dose intraportal infusion of hCiPSC-islets into …
Authors
Du Y; Liang Z; Wang S; Sun D; Wang X; Liew SY; Lu S; Wu S; Jiang Y; Wang Y
Journal
Nature Medicine, Vol. 28, No. 2, pp. 272–282
Publisher
Springer Nature
Publication Date
2 2022
DOI
10.1038/s41591-021-01645-7
ISSN
1078-8956