Journal article
Implications of OPRM1 and CYP2B6 variants on treatment outcomes in methadone-maintained patients in Ontario: Exploring sex differences
Abstract
Genetic variants in the OPRM1 and CYP2B6 genes, respectively coding for an opioid receptor and methadone metabolizers, have been linked to negative treatment outcomes in patients undergoing methadone maintenance treatment, with little consensus on their effect. This study aims to test the associations between pre-selected SNPs of OPRM1 and CYP2B6 and outcomes of continued opioid use, relapse, and methadone dose. It also aims to observe …
Authors
Chawar C; Hillmer A; Lamri A; Kapczinski F; Thabane L; Pare G; Samaan Z
Journal
PLOS ONE, Vol. 16, No. 12,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0261201
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AdultAllelesAnalgesics, OpioidCytochrome P-450 CYP2B6FemaleGene FrequencyGenotypeHumansLinkage DisequilibriumMaleMethadoneOntarioOpiate Substitution TreatmentOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Opioid, muRecurrenceSex CharacteristicsSex FactorsSubstance-Related DisordersTreatment Outcome