Journal article
Mesenchymal stem cells ameliorate β cell dysfunction of human type 2 diabetic islets by reversing β cell dedifferentiation
Abstract
BACKGROUND: A physiological hallmark of patients with type 2 diabetes mellitus (T2DM) is β cell dysfunction. Despite adequate treatment, it is an irreversible process that follows disease progression. Therefore, the development of novel therapies that restore β cell function is of utmost importance.
METHODS: This study aims to unveil the mechanistic action of mesenchymal stem cells (MSCs) by investigating its impact on isolated human T2DM …
Authors
Wang L; Liu T; Liang R; Wang G; Liu Y; Zou J; Liu N; Zhang B; Liu Y; Ding X
Journal
EBioMedicine, Vol. 51, ,
Publisher
Elsevier
Publication Date
January 2020
DOI
10.1016/j.ebiom.2019.102615
ISSN
2352-3964