Journal article
C3a, C5a Renal Expression and Their Receptors are Correlated to Severity of IgA Nephropathy
Abstract
BackgroundIgA nephropathy (IgAN) is the most common primary kidney disease, often leading to chronic renal failure. Complement activation products C3a and C5a have broad pro-inflammatory potential through their receptors, C3aR and C5aR, and contribute to the pathogenesis of several inflammatory and autoimmune diseases, but their roles in IgAN are poorly defined.PurposeThis study aimed to establish correlations between renal C3a, C5a, C3aR, …
Authors
Liu L; Zhang Y; Duan X; Peng Q; Liu Q; Zhou Y; Quan S; Xing G
Journal
Journal of Clinical Immunology, Vol. 34, No. 2, pp. 224–232
Publisher
Springer Nature
Publication Date
February 2014
DOI
10.1007/s10875-013-9970-6
ISSN
0271-9142